Photoinduced electron-transfer chemistry of the bielectrophoric N-phthaloyl derivatives of the amino acids tyrosine, histidine and tryptophan
نویسندگان
چکیده
The photochemistry of phthalimide derivatives of the electron-rich amino acids tyrosine, histidine and tryptophan 8-10 was studied with respect to photoinduced electron-transfer (PET) induced decarboxylation and Norrish II bond cleavage. Whereas exclusive photodecarboxylation of the tyrosine substrate 8 was observed, the histidine compound 9 resulted in a mixture of histamine and preferential Norrish cleavage. The tryptophan derivative 10 is photochemically inert and shows preferential decarboxylation only when induced by intermolecular PET.
منابع مشابه
Repair of oxidative DNA damage by amino acids.
Guanyl radicals, the product of the removal of a single electron from guanine, are produced in DNA by the direct effect of ionizing radiation. We have produced guanyl radicals in DNA by using the single electron oxidizing agent (SCN)2-, itself derived from the indirect effect of ionizing radiation via thiocyanate scavenging of OH. We have examined the reactivity of guanyl radicals in plasmid DN...
متن کاملTime-resolved CIDNP study of protein-related molecules
Time-resolved CIDNP and Laser Flash Photolysis have been applied to the investigation of the kinetics and mechanism of CIDNP formation in the reactions of aza-aromatic dye 2,2′-dipyridyl and protein-related molecules, including N-acetyl derivatives of three amino acids (tryptophan, tyrosine, histidine) the dipeptide tryptophan-tyrosine, and hen egg-white lysozyme in native and denatured states....
متن کاملComparison of Essential and Non Essential Amino Acids in the Microbial Protein of Pleurotus Florida from the Lignocellulosic Wastes
Introduction: Cereal straws contain Cellulose, Hemicelluloses and Lignin and are most available renewable biopolymers. White rot fungi is used to convert these wastes into microbial protein. Pleurotus Florida are having the most delignification ability amongst other micro-organisms. We determined the amounts of protein, essential and non essential amino acids of the produced microbial protein f...
متن کاملComparison of the Effect of Amino Acids and Their Derivatives on the Growth of Some Dermatophytes: An In Vitro Study
Background and Aims: Amino acids have different effects on the growth of some dermatophytes. Some may increase whereas others maydecrease their growth. The concentration of some amino acids is also an important factor for their effects. Materials and Methods: To investigate the effects of L-amino acids on the growth of six species of dermatophytes including Epidermophyton floccosum, Microspor...
متن کاملA Crystallization-Induced Asymmetric Transformation using Racemic Phenyl Alanine Methyl Ester Derivatives as Versatile Precursors to Prepare Amino Acids
L-Tyrosine and L-Dopa are the precursors in the biological synthesis of amine neurotransmitters. On the other hand, phenylalanine as an aromatic amino acid (AAA) is a precursor in the synthesis of L-Tyrosine and L-Dopa. For some substrates such as amino acids, resolution by the formation of diastereomers offers an attractive alternative. Among different methods in this case, crystallization-ind...
متن کامل